This is a list of special guest stars that appeared over the course of the series.

Guest Star Story Arcs
Samuel L. Jackson Ghost Story
Who Burned Mr. Brinker's Store?
Samaria Graham Ghost Story
Who's Who?
Mark Linn-Baker Ghost Story
Max Wright Who Burned Mr. Brinker's Store?
Jeremy Miller Who Burned Mr. Brinker's Store?
Captain Lou Albano Who Burned Mr. Brinker's Store?
Dulé Hill To Catch a Creep
Ellen Foley To Catch a Creep
Building Bridges
Who is Max Mouse?
David Patrick Kelly Into the Comics
To the Light
Spike Lee Into the Comics
Patricia Barry Who's Who?
Judge Reinhold Am I Blue?
Daisy Fuentes Am I Blue?
Bo Jackson Get the Message
Stephi Lineburg Just in Time
Cathy Rigby Lost in Brooklyn
Greg Lee Who is Max Mouse?
Julia Stiles Who is Max Mouse?
Annabelle Gurwitch Don't Stop the Music
Mia Korf Don't Stop the Music
Robin Leach Don't Stop the Music
Ed Lover & Dr. Dre Don't Stop the Music
Salt-n-Pepa Don't Stop the Music
The Rashad Family A Crime of Two Cities
CeCe Peniston Attack of the Slime Monster